April 2010

Headline News Innovation and Development

Applied Technology

Basic Science Cooperation between CAS and Local Authorities
Bioscience International Cooperation Brief News Geoscience  
Innovation and Development

Latest Modulation of Big Bang

On Mar. 30, Large Hadron Collider(LHC)successfully collided two beams of protons with a total energy of seven trillion electron volts. This is the highest energy-level proton beams’ collision experiment conducted in LHC so far. The collision would take several hours or even several days. According to the bulletin of the European Organization for Nuclear Research (CERN), scientists wished to recreate the conditions just after the Big Bang by colliding the two beams head-on at very high energy in the collider, in order to carry out in-depth research of the origin of the universe and the properties of various particles. As the largest one of its type in the world, LHC is located near Geneva, where it spans the border between Switzerland and France about 100 m underground. It is contained in a circular tunnel, with a circumference of 27 kilometers. Four detectors have been constructed in the tunnel, which are Compact Muon Solenoid (CMS), A Toroidal LHC Apparatus (ATLAS), LHC-beauty(LHCb)and A Large Ion Collider Experiment (ALICE). LHC was designed in early 1990s. About 7,000 scientists and engineers from over 80 countries and regions participated in the construction of LHC. China participated in the construction and experiments of all the four detectors.

New Mechanism for Anti-Cancer Drugs

Recently, more than 30 thiazolidinediones (TZDs) were identified as potent and high selective small-molecular IGF-1R inhibitors through a hierarchical virtual screening strategy developed with complementing pharmacophore-based screening and docking-based screening techniques, the established stable small-molecular IGF-1R inhibitors screening platform, structure activity relationship analysis, molecular biotechnology, cell biotechnology and other approaches and technologies. This research progress was collaboratively fulfilled by two research teams from the Shanghai Institute of Materia Medica (SIMM), CAS led separately by Jiang Hualiang and Ding Jian, and another team from the School of Pharmacy, East China University of Technology led by Li Honglin. A large number of epidemiological and pathological research has indicated that IGF-1 receptor is over-expressed in many types of human tumor cells due to the increase in insulin-like growth factor-1 (IGF-1), thereby increasing the risk of developing cancers. IGF-1R is a promising research target for cancer therapy; therefore, finding novel and high selective IGF-1R inhibitors maintains important clinical significance and sound application prospects. The result of this collaborative research laid a solid foundation for the development of new antitumor agents. The result was recently published on the latest issue of Journal of Medicinal Chemistry (2010, 53: 2661–2665). SIMM has formed a partnership with the School of Pharmacy, East China University of Technology in developing new antitumor drugs with IGF-1R as target for therapy. In addition to the result mentioned above, the collaborative research team has obtained more than 130 TDZ derivates through modification of the molecular structures.

Other Issues
Sixty-eighth Issue (February 2010)

Sixty-seventh Issue (December 2010)

Sixty-sixth Issue (October 2009)
Sixty-fifth Issue (August 2009)
Sixty-fourth Issue (June 2009)
Sixty-third Issue (April 2009)
Sixty-second Issue (February 2009)
Sixty-first Issue (December 2008)
Sixtieth Issue (October 2008)
Fifty-nineth Issue (August 2008)
Fifty-eighth Issue (June 2008)
Fifty-seventh Issue (April 2008)
Fifty-sixth Issue (February 2008)
Fifty-fifth Issue (December 2007)
Fifty-fourth Issue (October 2007)
Fifty-third Issue (August 2007)
Fifty-second Issue (June 2007)
Fifty-first Issue (April 2007)
Fiftith Issue (Feb. 2007)
Fourty-nineth Issue (December, 2006)
Fourty-eighth Issue (Ocboter, 2006)
Fourty-seventh Issue (August, 2006)
Fourty-sixth Issue (June, 2006)
Fourty-fifth Issue (April, 2006)
Fourty-fourth Issue (February, 2006)
Fourty-third Issue (December, 2005)
Fourty-second Issue (October, 2005)
Fourty-first Issue (August, 2005)
Fourtith Issue (June, 2005)
Thirty-ninth Issue (April, 2005)
Thirty-eighth Issue (February, 2005)
Thirty-seventh Issue (December, 2004)
Thirty-sixth Issue (October, 2004)
Thirty-fifth Issue (August, 2004)
Thirty-fourth Issue (June, 2004)
Thirty-third Issue (April, 2004)
Thirty-second Issue (February, 2004)
Thirty-first Issue (December, 2003)
Thirtieth Issue (October, 2003)
Twenty-nineth Issue (August, 2003)
Twenty-eighth Issue (June, 2003)
Twenty-seventh Issue (Spring, 2003)

copyright © 1998-2010
CAS Newsletter Editorial Board: 52, Sanlihe Road, Beijing 100864, CHINA