No. 81

April 2012

Headline News Innovation and Development

Applied Technology

Basic Science Cooperation between CAS and Local Authorities
Bioscience International Cooperation Brief News Geoscience

International Cooperation

Major Advancement in Protein Design

On Mar. 12, 2011, the German magazine Angewandte Chemie published online a paper entitled ¡°¡°Dramatic Increase of Oxidase Activity through the Genetic Incorporation of Tyrosine-Histidine Crosslink in a Myoglobin Model of Heme-Copper Oxidase¡±, which is the fruit of a collaboration of Wang Jiangyun¡¯s group at Institute of Biophysics and Yi Lu¡¯s group at the Department of Chemistry, University of Illinois at Urbana-Champaigny. By directly incorporating the unnatural amino acid imiTyr into myoglobins, the research has successfully designed a functional HCO model imiTyrCuBMb that catalyzes selective and efficient oxygen reduction to water. This work provides the first direct evidence of the post-translationally modified Tyr-His cross-link function in HCO. It is an important progress in the field of protein design, while relevant important application in bioenergetics is now expected.

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