No. 93

February 2014

Headline News Innovation and Development

Applied Technology

Basic Science

Cooperation between CAS and Local Authorities

Bioscience Exchanges with Hong Kong Brief News Geoscience Activities of CAS Leaders


Novel Centriolar Satellite Reorganization Mechanism Discovered

Dr. Jannie Danielsen from Prof. Yang Yungui's Group at the Laboratory of Genome Variations and Precision Biomedicine, Beijing Institute of Genomics, CAS, in collaboration with Prof. Mailand Niels from the University of Copenhagen, revealed that a new cellular stress response triggers centriolar satellite reorganization and ciliogenesis, published online in the EMBO J on Oct. 11, 2013. Centriolar satellites are small, granular structures that cluster around centrosomes, but whose biological function and regulation are poorly understood. They discover that centriolar satellites undergo striking reorganization in response to cellular stresses such as UV radiation, heat shock, and transcription blocks, invoking acute and selective displacement of the factors AZI1/CEP131, PCM1, and CEP290 from this compartment triggered by activation of the stress-responsive kinase p38/MAPK14. The researchers demonstrate that the E3 ubiquitin ligase MIB1 is a new component of centriolar satellites, which interacts with and ubiquitylates AZI1 and PCM1 and suppresses primary cilium formation. In response to cell stress, MIB1 is abruptly inactivated in a p38-independent manner, leading to loss of AZI1, PCM1, and CEP290 ubiquitylation and concomitant stimulation of ciliogenesis, even in proliferating cells. Collectively, these results uncover a new two-pronged signalling response, which by coupling p38-dependent phosphorylation with MIB1-catalysed ubiquitylation of ciliogenesis-promoting factors plays an important role in controlling centriolar satellite status and key centrosomal functions in a cell stress-regulated manner.

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